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KMID : 0603820120180040338
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 4 p.338 ~ p.344
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Mollugin-mediated Inhibition of Proinflammatory Biomarkers in Lipopolysaccharide-stimulated RAW264.7 Cells
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Kim Jin-Kyung
Park Geun-Mook
Jun Jong-Gab
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Abstract
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Mollugin is the active compound of Rubia cordifolia, a well known herb widely used in alternative medicines for the treatment of various inflammatory diseases including arthritis and uteritis. In the present study, we investigated the anti-inflammatory effects of mollugin in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage cells. Treatment with mollugin significantly inhibited LPS-induced release of nitric oxide, prostaglandin E2, and inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6. In addition, mollugin suppressed LPS-induced nuclear factor-kappa B (NF-κB) transcriptional activity. These results suggest that mollugin inhibits LPS-induced expression of inflammatory molecules via NF-κB, at least in part, and indicate the potential value of mollugin as a valuable new drug candidate for the treatment of various inflammatory diseases.
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KEYWORD
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Inflammation, Mollugin, IL-6, Nitric oxide
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